the Effect of Preoperative Sodium Ibuprofen on Postoperative Endodontic Pain

Cairo University (CU)

Status and phase

Completed

Phase 2

Phase 1

Conditions

Irreversible Pulpitis

Treatments

Drug: nurofen

Study type

Interventional

Funder types

Other

Identifiers

NCT04964622

postoperative endodontic pain

Details and patient eligibility

About

The aim of this study is to clinically compare post-operative pain levels after administration of preoperative single dose of sodium ibuprofen versus placebo for patient with symptomatic irreversible pulpitis related to mandibular molar teeth.

Full description

Oral pharmacologic agents have been the primary option, and the use of drugs has increased exponentially. Many pharmacological agents have been used to manage endodontic pain, including Non-steroidal Anti-inflammatory Drugs (NSAIDs),.administration of NSAIDs before root canal treatment will reduce inflammatory process before it begins. NSAIDs are widely used to control post endodontic pain They act by blocking the activity of cyclooxygenase (COX 1 and 2) enzyme. In human dental pulps with irreversible pulpitis, a higher level of expression of COX 2.In cases of irreversible pulpitis NSAIDS can be administered preoperatively since they reduce the level of prostaglandinE2(PGE2) which is responsible for sensitization of nociceptors. Ibuprofen is one of the most commonly used NSAIDs and a potent inhibitor of prostaglandin (PG) synthesis that can manage various pain types and has anti-inflammatory activity. Enhancements in ibuprofen acid's pharmacokinetics have led to the development of ibuprofen salts with a faster dissolution rate and onset of action. These ibuprofen salts.Fast acting ibuprofen like Sodium ibuprofen delivers maximum plasma drug concentrations at about 30-40 min, compared with around 90-120 min for standard ibuprofen acid formulations

Enrollment

50 patients

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients above 18 years old and below 66.
Male or female
Patients seeking root canal treatment
Mandibular posterior molarteeth with Symptomatic irreversible pulpitis .
Spontaneous pain
Systematically healthy patient(ASA I,II)

Exclusion criteria

Medically compromised patients having significant systemic disorders. (ASA III or IV)
History of intolerance to NSAIDS.
Patients with two or more adjacent teeth requiring endodontic treatment.
External root resorption
Internal root resorption
Vertical root fracture
Periapical lesion
Pregnancy
Use of ibuprofen in the last 12 hour
Bleeding disorder
Long term corticosteroid use
Mobility Grade II or III.
Pocket depth more than 5mm.
Previous root canal therapy.
Non-restorability
Temporomandibular joint (TMJ) problems, bruxism, clenching or traumatic occlusion.
Inability to perceive the given instructions.