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The Effect of Pressure Controlled Ventilation on the Pulmonary Mechanics in Prone Position Using the Wilson Frame: A Comparison With Volume Controlled Ventilation

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Yonsei University

Status

Completed

Conditions

Herniation of Lumbar Vertebral Disc

Treatments

Procedure: volume control
Procedure: pressure control

Study type

Interventional

Funder types

Other

Identifiers

NCT01272700
4-2010-0201

Details and patient eligibility

About

Prone position in spinal surgery can increase airway pressure and decrease dynamic lung compliance by a frame used for postural stabilization. Also, it can increase hemodynamic instability such as reduced blood pressure by aggravating cardiac index.

Former study shows pressure controlled ventilation on the pulmonary mechanics can improve alveolar use and oxygenation than volume controlled ventilation. The latter one means controlling a patient's breathing completely through tidal volume and set breathing rate. This could be useful for the patients not possible to breath by themselves because it guarantees the perfect breathing.

The pressure controlled ventilation is used when there is a possibility to change a patient's environment. The pressure will be maintained steadily, but volume and flux will be changed. That means through the pressure already set, the whole breathing will be maintained from the beginning to end. If a patient's resistance is increased, the volume will be decreased even though the way of blood pressure control is same. However, the tidal volume per minute can be controlled somewhat and barotrauma can be decreased by controlling respiratory rate. Through this study, we are expecting the pressure controlled ventilation in prone position can improve lung mechanics and oxygenation.

Enrollment

40 patients

Sex

All

Ages

20 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • scheduled for lumbar spine surgery under general anaesthesia

Exclusion criteria

  • Patients with coronary artery occlusive disease
  • morbid obesity (body mass index ≥ 30 kg/m2)
  • cerebrovascular disease and major obstructive or restrictive pulmonary disease

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

40 participants in 2 patient groups

PCV
Experimental group
Description:
Peak airway pressure were set to deliver a tidal volume of 10 ml/kg of ideal body weight
Treatment:
Procedure: volume control
VCV
Active Comparator group
Description:
After anesthetic induction, anesthesia maching were set to deliver a tidal volume of 10 ml/kg of ideal body weight
Treatment:
Procedure: pressure control

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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