The Effect of Priming Intravenous Rocuronium on Fentanyl-Induced Coughing

Taichung Armed Forces General Hospital

Status: Completed

Conditions: Fentanyl-induced Coughing

Treatments: Drug: Rocuronium

Study type: Interventional

Funder types: Other

Identifiers

NCT01532466

TC100-5

Details and patient eligibility

About

An intravenous bolus of fentanyl often induces a cough reflex. This study investigates whether priming with rocuronium can attenuate fentanyl-induced coughing effectively.

Full description

Fentanyl is widely used for analgesia and anesthesia because of its rapid onset, its intense analgesic effect, and is associated with lessened cardiovascular depression and low histamine release. Although the cough reflex is usually transient and self-limiting, it should be avoided in situations such as elevated intracranial, intraocular, or intra-abdominal pressure, and unstable hemodynamics.

The cause of FIC is unclear. One hypothesis is that vocal cord spasms might induce coughing because of fentanyl-induced muscle rigidity and histamine release. Muscle relaxants are commonly used to treat this condition. This study hypothesizes that priming muscle relaxants could prevent or suppress FIC. This study investigates whether the muscle relaxant rocuronium attenuates FIC effectively.

Enrollment: 260 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 260 ASA I-II patients,
• aged between 18 and 80 years, and undergoing various elective surgeries at Taichung Armed Forces General Hospital.

Exclusion criteria

• a history of asthma,
• chronic cough,
• smoking,
• upper respiratory tract infection in the previous 2 weeks, and
• medication containing angiotensin-converting enzyme inhibitors or anesthetic premedication.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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260 participants in 2 patient groups

Rocuronium, fentanyl-induced cough, normal saline

Experimental group

Description:

All patients were given oxygen via a face mask. The patients were then administered with the following medications intravenously: the rocuronium group received rocuronium 0.06 mg kg-1 30 s before the injection of an IV fentanyl bolus (1.5 mcg kg-1, within 2 s).

Treatment:

Drug: Rocuronium

Normal saline

No Intervention group

Description:

All patients were given oxygen via a face mask. The patients were then administered with the following medications intravenously: the control group received the same volume of normal saline 30 s before the injection of an IV fentanyl bolus (1.5 mcg kg-1, within 2 s).