The Effect of ProHydrolase® on the Amino Acid, Intramuscular Anabolic Signaling, and Endocrine Response to Resistance Exercise in Trained Males

Deerland Probiotics & Enzymes

Status: Completed

Conditions: Amino Acids

Treatments: Dietary Supplement: Whey protein; Dietary Supplement: Placebo; Dietary Supplement: ProHydrolase®

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT04144114

Pro18

Details and patient eligibility

About

To examine the amino acid absorption following acute resistance exercise between three supplemental treatments: 1) Whey Protein + ProHydrolase (WPH) 2) Whey Protein (W) and 3) Non-Caloric Placebo (PL). To examine three supplemental treatments (WPH, W, PL) in conjunction with acute resistance exercise on the mTORC1 complex pathway. To examine three supplemental treatments (WPH, W, PL) in conjunction with acute resistance exercise on circulating concentrations of endocrine biomarkers.

Enrollment: 10 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• • At least one-year of resistance training experience

  • Free of any physical limitations (determined by health and activity questionnaire).
  • Between the ages of 18 and 35.
  • Ability to leg press a weight equivalent to 1.5 times their body mass

Exclusion criteria

• • Inability to perform physical exercise (determined by health and activity questionnaire)

  • Taking any other nutritional supplement or performance enhancing drug (determined from health and activity questionnaire).
  • Physical injury preventing the athlete from participating in offseason training
  • Any chronic illness that causes continuous medical care

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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10 participants in 3 patient groups, including a placebo group

Whey + ProHydrolase®

Experimental group

Description:

Subjects received 250mg of ProHydrolase® along with 25g of whey protein mixed in a drink every visit for 4 weeks

Treatment:

Dietary Supplement: ProHydrolase®

Whey

Active Comparator group

Description:

Subjects received 25g whey protein in a drink every visit for 4 weeks

Treatment:

Dietary Supplement: Whey protein

Placebo

Placebo Comparator group

Description:

Subjects received 25g maltodextrin in a drink every visit for 4 weeks

Treatment:

Dietary Supplement: Placebo