The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide

Yonsei University

Status and phase: Completed; Phase 4

Conditions: Prostate Cancer

Treatments: Drug: propofol; Drug: Desflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02149628

3-2013-0098

Details and patient eligibility

About

Robot assisted laparoscopic radical prostatectomy(Robot-LRP) requires pneumoperitoneum and trendelenburg position which result in oxidative stress and inflammatory response.

Propofol is well known to reduce those responses during anesthesia. Therefore, we try to figure out the efficacy of propofol to reduce oxidative stress, inflammatory response and increase the nitric oxide activity during robot-LRP compared to that of desflurane.

To investigate the oxidative stress, malondialdehyde will be measured. As inflammatory markers, interleukin-1β, interleukin-6, tumor necrosis factor-α will be measured. Nitric oxide will be measured as well.

Secondarily, kidney protection effect of propofol over desflurane will be compared.

Enrollment: 50 patients

Sex: Male

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing robot-assisted laparoscopic radical prostatectomy under general anesthesia

Exclusion criteria

• chronic renal failure ( estimated glomerular filtration rate <60 mL/min/1.73m2)
• allergy to propofol, nuts
• on diuretics, vitamin C or vitamin E within 5 days before surgery
• Body mass index > 30 kg/m2
• older than 70 years
• who cannot read the patient consent form

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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50 participants in 2 patient groups

desflurane

Active Comparator group

Description:

use desflurane as a primary anesthetics during anesthesia guided by bispectral index (BIS)

Treatment:

Drug: Desflurane

propofol

Experimental group

Description:

propofol infusion with target-controlled infusion(TCI) device guided by BIS

Treatment:

Drug: propofol