The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury

Diskapi Teaching and Research Hospital

Status and phase: Completed; Phase 4

Conditions: Tourniquet-Induced Ischemia-Reperfusion Injury; Total Knee Arthroplasty

Treatments: Drug: Propofol; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01638624

Diskapi2012

Details and patient eligibility

About

The release of tourniquet produces reactive oxygen species which can cause injury. Propofol is chemically similar to phenol-based free radical scavengers.

Plasma total antioxidant capacity is a well-established marker of the overall protective effect of antioxidants in body fluids.The aim of the study is to investigate the effects of propofol on ischemia-reperfusion injury in total knee arthroplasty (TKA).

Enrollment: 36 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-II physical status
• Unilateral total knee arthroplasty
• Age 18 years to 80 years

Exclusion criteria

• Severe central nervous system disorders
• Severe cardiopulmonary,renal,metabolic, or hepatic disease,
• Blood volume deficits,
• Coagulopathy,
• Allergy to local anesthetics,
• Peripheral neuropathies,
• Body mass index > 35,
• History of antioxidant drug use

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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36 participants in 2 patient groups, including a placebo group

Propofol

Active Comparator group

Description:

Propofol infusion group: Under spinal anesthesia, a continuous intravenous infusion (2mg/kg/h) of propofol will be use during the operation

Treatment:

Drug: Propofol

Control group

Placebo Comparator group

Description:

Placebo group: Under spinal anesthesia, a continuous intravenous infusion of volume-equivalent placebo will use during the operation

Treatment:

Drug: Placebo