The Effect of Propofol or Sevoflurane on Renal Function

Uppsala University

Status and phase: Completed; Phase 4

Conditions: Acute Kidney Injury; Anesthesia

Treatments: Drug: Sevoflurane; Procedure: Back Surgery; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT03336801

ANIMAL-523-2014-2569

Details and patient eligibility

About

This study investigates the role of the anesthetic agents propofol and sevoflurane on renal function in otherwise healthy patients undergoing basic back surgery.

Full description

Water-sodium homeostasis is central for anyone undergoing surgery, and can therefore affect surgical outcome, level of postoperative care and the length of hospital stay. Too much or too little fluid during surgery can affect the patients negatively. The kidneys play an imperative role in the regulation of water and sodium homeostasis, however there are lack of knowledge in how the anesthesia per se affects renal function. Previous studies have shown that volatile anesthetic agents such as sevoflurane can cause fluid retention. Why this happens is not completely known.

We are now investigating the different affects of sevoflurane and propofol anesthesia on renal function in patients undergoing basic back surgery to elucidate if there is a difference in the risk of developing acute kidney injury.

Enrollment: 37 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Scheduled back surgery

Exclusion criteria

• American Association of Anesthesiology class 1-3
• American Heart Association class >3
• BMI >37
• Insulin treated diabetes
• Pregnancy or breast feeding
• Sensistivity/allergy against anesthetic agents
• Inadequate understanding about the study
• Depressed kidney function and/or AKI
• Depressed liver function
• Genetic malignant hyperthermia

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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37 participants in 2 patient groups

Sevoflurane

Active Comparator group

Description:

Intervention Back surgery and sevoflurane.

Treatment:

Procedure: Back Surgery

Drug: Sevoflurane

Propofol

Active Comparator group

Description:

Intervention Back surgery and propofol.

Treatment:

Procedure: Back Surgery

Drug: Propofol