The Effect of Psoriatic Arthritis on Female Sexual Dysfunction

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Status: Not yet enrolling

Conditions: Psoriatic Arthritis

Treatments: Behavioral: The effect of psoriatic Arthritis

Study type: Observational

Funder types: Industry

Identifiers

NCT06370221

psoriatic Arthritis

Details and patient eligibility

About

Psoriasis is one of the most common immunemediated chronic inflammatory skin disorders.

Full description

Psoriasis is one of the most common immunemediated chronic inflammatory skin disorders.

Beside genetic factors, several environmental factors such as injuries, infections, stress, drugs, and immune defect take part in autoimmune pathogenesis of the disease. In addition, it has been reported that some hormones may also have a role in the pathogenesis of psoriasis, due to their effects on keratinocytes proliferation.

Studies revealed that sex hormones manifest a variety of biological and immunological effects in the skin which modulate the natural course of psoriasis.

Approximately 20-30% of patients with psoriasis may also have psoriatic arthritis, which often causes significant musculoskeletal pain that significantly impairs quality of life (QoL).

Although sexual dysfunction is a common complaint, affecting 30 to 70% of psoriasis patients, few studies have analyzed the impact of psoriasis and psoriatic arthritis on quality of sexual life.

Enrollment: 180 estimated patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• The study will focuses on the relationship between the FSD and PsA;
• The healthy controls will derive from a population within the same geographic area and ethnic background as PsA;
• Used the same questionnaires/instruments of FSFI to diagnose FSD

Exclusion criteria

• pregnancy,
• breastfeeding
• being sexually inactive
• having a partner with sexual dysfunction,
• refusing to participate, or
• being unable to read
• Females with any sexual transmitted disease

Trial design

180 participants in 2 patient groups

Group A: Cases Group

Description:

About 100 patient females suffering from Psoriatic arthritis and to investigate the correlation between sex hormones profile ( estrogen and progesterone level) and female sexual function in Psoriatic arthritis patients

Treatment:

Behavioral: The effect of psoriatic Arthritis

Group B: Control Group

Description:

About 80 healthy control females

Treatment:

Behavioral: The effect of psoriatic Arthritis