The Effect of PXR Activation on Blood Pressure Regulation

University of Oulu

Status and phase: Completed; Phase 4

Conditions: Blood Pressure Regulation

Treatments: Drug: Placebo; Drug: Rifampicin

Study type: Interventional

Funder types: Other

Identifiers

NCT01690104

Rifa-BP

2011-005522-22 (EudraCT Number)

Details and patient eligibility

About

We are investigating the effects of pregnane X receptor (PXR) activation on the regulation of blood pressure in healthy volunteers. Rifampicin (an antibiotic and also an efficient PXR activator) and placebo will be given for a week to volunteers and blood pressure is measured 24 hours using an ambulatory blood pressure monitor. Blood pressure regulating hormones will be measured in blood. Our hypothesis is that PXR is involved in the regulation of blood pressure.

Enrollment: 22 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers
• BMI 19-30 kg/m2
• Age 18-40 years
• Systolic blood pressure 95 - 140 mmHg

Exclusion criteria

• Any continuous medication
• Any significant medical condition as judged by the study physician
• Diastolic blood pressure over 90 mmHg
• Sensitivity to rifampicin
• Pregnancy and lactation
• Difficult venipuncture
• Abuse of alcohol or medications, or drug use.
• Participation in other trial with medications in previous 30 days

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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22 participants in 2 patient groups, including a placebo group

Rifampicin

Active Comparator group

Description:

Rifampicin 600 mg daily

Treatment:

Drug: Rifampicin

Placebo

Placebo Comparator group

Description:

Placebo daily

Treatment:

Drug: Placebo