The Effect of Recruitment Maneuver With Protective Ventilation During Thoracic Surgery

Seoul National University

Status: Completed

Conditions: Inflammation; Mechanical Ventilation Complication; Thoracic Surgery

Treatments: Procedure: Recruitment maneuver combined with protective ventilation; Procedure: protective ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT01630395

JHBahk_recruitment maneuver

Details and patient eligibility

About

The purpose of this study is to determine if a recruitment maneuver combined with protective ventilatory strategy could reduce the pulmonary and systemic inflammatory responses to one-lung ventilation during thoracic surgery.

Enrollment: 60 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 20 Years and older
• Patients undergoing thoracic surgery

Exclusion criteria

• Emergency surgery
• Heart failure
• Pulmonary hypertension
• Forced vital capacity or forced expiratory volume in 1 sec < 50% of the predicted values
• Coagulation disorder
• Pulmonary or extrapulmonary infections
• History of treatment with steroid in 3 months before surgery
• History of recurrent pneumothorax
• History of lung resection surgery

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 3 patient groups

conventional

No Intervention group

Description:

Two-lung ventilation: tidal volume = 10 ml/kg, no PEEP. One-lung ventilation: tidal volume = 10 ml/kg, no PEEP

Protective

Active Comparator group

Description:

Two-lung ventilation: tidal volume 8 ml/kg, PEEP of 5 cmH2O. One-lung ventilation: tidal volume 6 ml/kg, PEEP of 5 cmH2O.

Treatment:

Procedure: protective ventilation

Recruitment

Active Comparator group

Description:

Two-lung ventilation: tidal volume 8 ml/kg, PEEP of 5 cmH2O. One-lung ventilation: tidal volume 6 ml/kg, PEEP of 5 cmH2O. Recruitment maneuver will be applied during one-lung ventilation.

Treatment:

Procedure: Recruitment maneuver combined with protective ventilation