The Effect of Regional Anaesthesia and Genetic Factors in the Development of Chronic Pain Following Total Knee Arthroplasty

Sciberras, Stephen M.D.

Status: Active, not recruiting

Conditions: Arthroplasty, Replacement, Knee; Chronic Pain Post-Proceduraal

Treatments: Procedure: Spinal anaesthesia; Procedure: General anaesthesia

Study type: Interventional

Identifiers

NCT04206046

001

Details and patient eligibility

About

The study aims to assess the effect of spinal anaesthesia against a general anaesthesia with a femoral block, with respect to the incidence of chronic pain following a total knee replacement.

It will also focus on genetic factors and their influence on chronic pain.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients able to undergo a total knee arthroplasty

Exclusion criteria

• age more than 75 years
• known case of chronic pain syndromes
• arthroplasty not due to osteoarthritis
• sensitivity to any drugs used in protocol

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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200 participants in 2 patient groups

General Anaesthesia

Active Comparator group

Description:

Patients will receive a general anaesthetic, together with a femoral nerve block.

Treatment:

Procedure: General anaesthesia

Spinal Anaesthesia

Active Comparator group

Description:

Patients will receive a spinal anaesthetic

Treatment:

Procedure: Spinal anaesthesia