The Effect of Remifentanil on Rebound Pain

Seoul National University

Status: Completed

Conditions: Pain, Postoperative

Treatments: Drug: Not used remifentanil infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT04236323

1912-041-1087

Details and patient eligibility

About

The investigators will evaluate the influence of intraoperative remifentanil infusion on the postoperative hyperalgesia in patients receiving rotator cuff repair after brachial plexus block for postoperative analgesia.

Full description

The study will include 68 patients undergoing rotator cuff repair. All patients will receive brachial plexus block for postoperative analgesia, followed by general anesthesia. In the experimental group, remifentanil infusion will not be used intraoperatively, and in the control group, remifentanil will be infused. After surgery, both groups will be given the same postoperative pain management using patient controlled analgesia(PCA), and pain patterns will be assessed using the Numerical rating scale (NRS) at 4 hour intervals for 24 hours. The primary end point of this study is the total dose of PCA medication over 24 hours.

Enrollment: 68 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ASA class I,II,III
• Patients undergoing arthroscopic rotator cuff repair surgery under general anesthesia after interscalen brachial plexus block for post operative analgesia
• Age ranges from 20 to 70

Exclusion criteria

• Patients who didn't agree to study
• Patients can't control PCA(Patient-Controlled-Analgesia) independently
• Patients who have conciousness disorder or can't express their pain level by NRS(Numeric Rating Scale) system
• Patients who have severe respiratory disease or hepatic failure
• Patinets who have known neuropathy or coagulopathy
• Pregnancy
• Patients with allegies to the drugs used in this study

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

68 participants in 2 patient groups

not used intraoperative remifentanil infusion

Experimental group

Description:

Adult patients aged \< 70 years and ASA class \< III undergoing rotator cuff repair not used intraoperative remifentanil infusion

Treatment:

Drug: Not used remifentanil infusion

used intraoperative remifentanil infusion

No Intervention group

Description:

Adult patients aged \< 70 years and ASA class \< III undergoing rotator cuff repair used intraoperative remifentanil infusion maintaining target concentration of 2-6ng/ml