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The Effect of Remote Ischemic Preconditioning on Postoperative Cognitive Dysfunction in Total Knee Replacement

K

Konkuk University Medical Center

Status

Completed

Conditions

Knee Osteoarthritis

Treatments

Procedure: Remote ischemic preconditioning

Study type

Interventional

Funder types

Other

Identifiers

NCT02478216
KUH1160078

Details and patient eligibility

About

The patients were allocated randomly to receive remote preconditioning group (RIPC group, R) or not (Control group, C) using sealed envelopes with the options inside the sealed envelope of R and C before anaesthesia induction. The registered nurse who did not participate in patient care and was blind to the study performed the all randomization process. All medical staffs who involved the patient care were blind to the study. All data were collected by trained observers who were blind to the study and did not participate in patient care

Full description

RIPC was performed just after anesthesia induction and before the tourniquet application for the operation site. The tourniquet was applied at the opposite site of thigh in the both groups. The thigh was covered with blanket to conceal the tourniquet inflation and deflation. For R group, 3 cycles of tourniquet inflation for 5 minutes with 2 × systemic systolic arterial blood pressure of arrival at operation room and deflation were performed. For C group, the tourniquet was applied with same manner for R group except inflation pressure of 0 mmHg. The tourniquet pressure according to the randomization was set by the registered nurse who participated in the patients' allocation. The monitor of tourniquet pressure was sealed for blindness.

Enrollment

72 patients

Sex

All

Ages

30+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • patient who was planned to undergo total knee replacement surgery

Exclusion criteria

  • emergency operation
  • underlying cerebrovascular disease
  • underlying peripheral vascular disease

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

72 participants in 2 patient groups

C group
No Intervention group
Description:
Remote ischemic preconditioning will not be applied
R group
Experimental group
Description:
Remote ischemic preconditioning will be applied.
Treatment:
Procedure: Remote ischemic preconditioning

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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