The Effect of Remote Postconditioning on Graft Function in Patients Undergoing Living-related Kidney Transplantation

Samsung Medical Center

Status: Completed

Conditions: Kidney Transplantation; Remote Ischemic Postconditioning; Ischemic Reperfusion Injury

Treatments: Device: remote ischemic postconditioning

Study type: Interventional

Funder types: Other

Identifiers

NCT01363687

2011-03-047

Details and patient eligibility

About

The purpose of this study is to investigate whether upper limb ischemic postconditioning can improve renal function and decrease ischemic-reperfusion injury in patients undergoing living donor kidney transplantation.

Full description

Ischemic reperfusion injury after kidney transplantation is a common clinical problem associated with a high morbidity and mortality. To reduce the adverse effect of ischemic reperfusion injury after organ transplantation, various strategies including ischemic preconditioning or postconditioning. Remote ischemic postconditioning is one of such strategies where brief ischemic reperfusion injury of one organ protects other organs from sustained ischemic reperfusion injury. Remote ischemic postconditioning of the limb with a tourniquet is a safe and convenient method of postconditioning organs against ischemic reperfusion injury. However, the efficacy of remote ischemic postconditioning in patients undergoing living donor kidney transplantation needs to be established. Therefore, we investigate the efficacy of remote ischemic postconditioning of the upper limb with a tourniquet in recipients of kidney transplantation by measuring the markers of acute kidney injury.

Enrollment: 60 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects undergoing elective living donor kidney transplantation
• subjects older than 20 yrs who can give written informed consent

Exclusion criteria

• re-transplant recipients
• those with peripheral vascular disease affecting the upper limbs free of arteriovenous fistula

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Remote ischemic postconditioning group

Experimental group

Description:

Recipients receive remote ischemic postconditioning after declamping of renal artery during kidney transplantation

Treatment:

Device: remote ischemic postconditioning

Control group

No Intervention group

Description:

Patients who have a deflated cuff placed on the upper limb free of arteriovenous fistula during the surgery