The Effect of Resistance Training on Muscle Strength and Nutritional Status in Patients With Liver Cirrhosis

University of Aarhus

Status: Unknown

Conditions: Liver Cirrhosis

Treatments: Behavioral: Nutrition and strength training; Behavioral: Nutrition

Study type: Interventional

Funder types: Other

Identifiers

NCT02343653

Training/Cirrhosis

Details and patient eligibility

About

The purpose is to investigate the effect of strength training on muscle strength, muscle mass and nutritional status in patients with liver cirrhosis to clarify possible metabolic and inflammatory changes during this intervention. In addition the investigator examine if the intervention is associated with fewer hospital readmission and an improved quality of life.

Enrollment: 39 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cirrhosis, Child Pugh score A and B

Exclusion criteria

• Cirrhosis, Child-Pugh score C at inclusion
• Neurological and/or psychiatric disorder
• Pregnancy, breastfeeding
• Patients with malignancy
• Patients with hepatic encephalopathy at inclusion
• Patients with atypical diets, such as vegans

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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39 participants in 2 patient groups

Nutrition

Active Comparator group

Description:

Participants receive a controlled diet consisting of 1.2-1.5 g of protein/kg/day for 12 weeks according to guidelines for enteral nutrition and patients with cirrhosis. The group receives dietary guidance and protein supplements.

Treatment:

Behavioral: Nutrition

Nutrition and strength training

Experimental group

Description:

Participants in this group receive same controlled diet consisting of 1.2-1.5 g of protein/kg/day for 12 weeks as the "No intervention"-group. Participants will also receive supervised strength training 3 x 60 min./week for 12 weeks. The group receives dietary guidance and protein supplements, which on training days should be consumed within 30 minutes after exercise.

Treatment:

Behavioral: Nutrition and strength training