The Effect of Resistance Training on Proprotein Subtilisin Convertase Kexin 9 Level After Coronary Bypass Surgery

National Cardiovascular Center Harapan Kita Hospital Indonesia

Status: Completed

Conditions: Coronary Artery Disease

Treatments: Behavioral: resistance training; Behavioral: aerobic training

Study type: Interventional

Funder types: Other

Identifiers

NCT02674659

RUHK-2016

Details and patient eligibility

About

This research add resistance training to patients who undergo cardiac rehabilitation program after coronary bypass surgery, comparing the level of PCSK9 level on that group to another group who receives conventional rehabilitation program (only aerobic exercise)

Full description

The PCSK9 level measured before and after cardiac rehabilitation program (around 3-4 weeks), and compared between two groups. ELISA method will be used to measure plasma PCSK9 level.

Resistance training will be given by professional trainer in gymnasium of National Cardiovascular Center Harapan Kita supervised by cardiologists, following rules from American College of Sports Medicine guideline regarding to exercise after cardiac event.

Enrollment: 87 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• post elective coronary artery bypass surgery
• > 18 years old
• sign informed consent

Exclusion criteria

• contraindications of resistance training (unstable angina, uncontrolled blood pressure (systolic > 160 mmHg diastolic > 100 mmHg), acute heart failure, pulmonary diseases, arrhythmia malignant)
• musculoskeletal pain, visual analog scale >3
• post congenital heart disease surgery
• post elective coronary artery bypass surgery with malfunction valves (operated or not)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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87 participants in 2 patient groups

Control group

Experimental group

Description:

Patients after coronary bypass surgery who undergo conventional cardiac rehabilitation program (aerobic training only)

Treatment:

Behavioral: aerobic training

Intervention group

Experimental group

Description:

Patients after coronary bypass surgery who undergo conventional cardiac rehabilitation program plus resistance training (aerobic and resistance training as well)

Treatment:

Behavioral: resistance training

Behavioral: aerobic training