The Effect of Restrictive Fluid and Vasopressin During Surgery of Burn Patients

Hangang Sacred Heart Hospital

Status: Unknown

Conditions: Burn Surgery

Treatments: Drug: Vasopressin

Study type: Interventional

Funder types: Other

Identifiers

NCT03590873

2018-051

Details and patient eligibility

About

This is a randomized double-blinded study to investigate in which the groups are designated as the control group and the restrictive group to further evaluate significant differences in intraoperative blood loos during burn surgery.

Full description

This is a randomized double-blinded study to investigate the effect of fluid restriction and vasopressin on blood loss during surgery of the burn patients. The groups are designated as the control group and the restrictive group to further evaluate significant differences in intraoperative blood loss during the surgery.

Enrollment: 158 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age ≥ 18 years old
• burn patients undergoing surgery (TBSA > 20%)

Exclusion criteria

• age < 18 years old
• history of renal disorder
• history of cardiac disorder

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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158 participants in 2 patient groups

Control group

No Intervention group

Description:

Intraoperative fluid management: administration of 6-10 ml/kg/hr of crystalloid solution.

Restrictive group

Experimental group

Description:

Intervention: administration of vasopressin 0.01 - 0.04 U/min after induction of anesthesia. Intraoperative fluid management: administration of 2-4 ml/kg/hr of crystalloid solution.

Treatment:

Drug: Vasopressin