The Effect of Rosuvastatin on Adenosine Metabolism

Radboud University Medical Center

Status: Completed

Conditions: Adenosine Metabolism

Treatments: Drug: placebo; Drug: rosuvastatin

Study type: Interventional

Funder types: Other

Identifiers

NCT00554138

Rosudip01

Details and patient eligibility

About

The aim of this study is to show whether rosuvastatin influences adenosine metabolism. Therefore we will determine whether rosuvasatin increases dipyridamole-induced vasodilation by increased adenosine receptor stimulation.

Enrollment: 24 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 18 - 50 years
• Signed informed consent

Exclusion criteria

• hypertension
• hypercholesterolemia
• diabetes Mellitus
• alanine aminotransferase > 90 U/L
• creatinine Kinase > 440 U/L
• cardiovascular disease
• GFR < 80 ml/min

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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24 participants in 2 patient groups, including a placebo group

1

Placebo Comparator group

Treatment:

Drug: placebo

2

Experimental group

Treatment:

Drug: rosuvastatin