The Effect of Rosuvastatin on Aortic Stiffness in Hemodialysis Patients in the AURORA Study

AstraZeneca

Status and phase: Completed; Phase 3

Conditions: Hypercholesterolemia

Treatments: Procedure: aortic pulse wave velocity measurements; Drug: Rosuvastatin

Study type: Interventional

Funder types: Industry

Identifiers

NCT00240279

4522IL/0096 Dutch SubStudy

D3562C00096

Details and patient eligibility

About

To investigate the effect of rosuvastatin compared to placebo on the aortic stiffness in hemodialysis patients as measured by pulse wave velocity (at 3, 6 and 12 months)

Sex: All

Ages: 50 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Signed informed consent, between 50 and 80 years of age, end stage renal failure patients receiving hemodialysis

Exclusion criteria

• Received statins within past 6 months, a clear indication for use of lipid altering drug, contra indication for lipid altering drug, history of statin induced myopathy items in very

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind