The Effect of Roux-en-Y Gastric Bypass on Bone Turnover

Hvidovre University Hospital

Status: Unknown

Conditions: Obesity; Gastric Bypass Surgery; Bone Loss

Treatments: Procedure: Roux-en-Y gastric bypass

Study type: Observational

Funder types: Other

Identifiers

NCT03046147

KBM-IS-Bone

Details and patient eligibility

About

Bone mineral density (BMD) is decreased after Roux-en-Y gastric bypass (RYGB) but whether RYGB induces changes in BMD beyond adaptation to major weight loss is not known. We aim to investigate BMD changes in weight bearing (hip, lumbal columna) and in non-weight bearing (forearm) regions before and after maximal weight loss at 1 year and after weight stabilisation at 4 years after RYGB. Moreover, plasma markers of bone turnover will be studied at fasting and during oral glucose tolerance test.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participation in previos study ((NCT 01202526)

Exclusion criteria

• Treatment of osteoporosis

Trial design

20 participants in 2 patient groups

RYGB patients with preoperative type diabetes

Description:

Recruited from a previously investigated cohort (NCT 01202526)

Treatment:

Procedure: Roux-en-Y gastric bypass

RYGB patients with preoperative normal glucose tolerance

Description:

Recruited from a previously investigated cohort (NCT 01202526)

Treatment:

Procedure: Roux-en-Y gastric bypass