The Effect of Roux-en-Y Gastric Bypass on Mitochondrial Function in Type 2 Diabetes

Hvidovre University Hospital

Status: Unknown

Conditions: Obesity; Type 2 Diabetes

Study type: Observational

Funder types: Other

Identifiers

NCT01468116

MITBypass

Details and patient eligibility

About

Roux-en-Y gastric bypass (RYGB) surgery induces resolution of type 2 diabetes, often within days after surgery and before significant weight loss. The aim of this study is to investigate whether changes in mitochondrial function contributes to the early improvement of type 2 diabetes after RYGB.

Full description

Mitochondrial dysfunction has been linked to development of insulin resistance in the muscle and hence to the pathogenesis of type 2 diabetes. Mitochondrial function can be studied non-invasively by 31 Phosphor Magnetic Resonance spectroscopy (31PMRS). In this study we will investigate changes in mitochondrial function using the combination of 31 PMRS and Near Infra-Red Spectroscopy (NIRS) after gastric bypass.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients eligible for gastric bypass surgery or cholecystectomy
• Verified type 2 diabetes or normal glucose tolerance by OGTT

Exclusion criteria

• Patients unable to fit the dimensions of the MRI-scanner

Trial design

30 participants in 3 patient groups

RYGB patients with type 2 diabetes

Description:

Morbidly obese patients with type 2 diabetes undergoing gastric bypass surgery

RYGB patients without type 2 diabetes

Description:

Morbidly obese patients with normal glucose tolerance undergoing gastric bypass surgery

Cholecystectomy patients without type 2 diabetes

Description:

Patients with normal glucose tolerance undergoing laparoscopically cholecystectomy