The Effect of rPMS on Motor Skill Performance in Persons With a Stroke.

University of Illinois

Status: Completed

Conditions: Stroke

Treatments: Other: Repetitive Peripheral Magnetic Stimulation (rPMS); Other: Sham Priming

Study type: Interventional

Funder types: Other

Identifiers

NCT05833490

2022-0600

Details and patient eligibility

About

In the past two decades, even as stroke cases increase around the world, advances in motor rehabilitation have been limited. Clinical trials of stroke rehabilitation have examined the therapeutic utility of several neuromodulatory devices to improve efficacy of motor training. However, there is limited knowledge on the effects of sensory-based priming techniques using repetitive peripheral magnetic stimulation (rPMS) post stroke. This project focuses on understanding the effect of rPMS on motor skill performance in persons with stroke.

Full description

The central hypothesis of this study is that rPMS is a suitable priming technique for enhancing motor skill performance in individuals with stroke. The investigators plan to test our hypothesis by pursuing the following specific aim:

To determine whether rPMS can facilitate lower limb's motor skill performance more than sham rPMS in individuals with stroke.

Hypothesis: The effect of stimulation on lower limb's motor skill performance will be measured using a visuomotor tracking task at different time points: baseline, immediately after, at 30 minutes, and 60 minutes after stimulation. Individuals with stroke during the rPMS condition will demonstrate greater motor skill performance following rPMS and will be able to sustain the enhanced performance at 30 and 60 minutes after the stimulation, compared to sham condition.

This study will improve our understanding of the effects of rPMS, thus encouraging the use of a single session of rPMS as a priming tool to enhance motor skill performance. The proposal is important as it is the first to study the time course effects of rPMS on lower limb's motor skill performance in stroke populations.

Enrollment: 36 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosed mono-hemispheric stroke
• More than 3 months since stroke onset.
• Participants must demonstrate adequate cognitive abilities to be able to follow the protocol (21>MMSE).

Exclusion criteria

• Individuals with lesions affecting the brainstem or cerebellum.
• Other musculoskeletal or neurological impairments such as (Alzheimer, Parkinson, etc.).
• Complete paralysis that would limit the participant's' ability to perform motor skill tasks.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Sequential Assignment

Masking: Single Blind

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36 participants in 2 patient groups

Sensory-based priming

Experimental group

Description:

Participants will receive rPMS at 10% above motor threshold with the coil placed on the Tibialis Anterior muscle belly. rPMS parameters will be: 40 trains, intermittently (3) seconds on, (19) seconds off, with an intensity \~10% above motor threshold.

Treatment:

Other: Repetitive Peripheral Magnetic Stimulation (rPMS)

Sham Priming

Sham Comparator group

Description:

Participants will receive sham rPMS at a very low intensity with the coil placed on the dorsal part of the foot. rPMS parameters will be: 40 trains, intermittently (3) seconds on, (19) seconds off, with an intensity at 5% of maximum stimulator output.

Treatment:

Other: Sham Priming