The Effect of Sedation on Eye Movements

The University of Alabama at Birmingham

Status: Completed

Conditions: Saccadic Eye Movements

Treatments: Drug: saline placebo; Drug: dexmedetomidine; Drug: Midazolam; Drug: propofol

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00646646

K23RR021874-01A1 (U.S. NIH Grant/Contract)

F050721005

Details and patient eligibility

About

The purpose of this study is to determine whether sedation affects saccadic eye movements.

Enrollment: 65 patients

Sex: All

Ages: 19 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy, human volunteers, age 19-65.
• American Society of Anesthesiology (ASA) class I-II for inclusion criteria

Exclusion criteria

• Pregnancy
• Respiratory disease (severe asthma, emphysema)
• Cardiac disease (coronary artery disease, congestive heart failure)
• Symptomatic reflux disease
• Advanced rheumatic disease involving cervical spine
• Propofol or egg allergy
• Neurological disease (stroke, intracranial processes)
• Severe anemia

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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65 participants in 4 patient groups, including a placebo group

propofol

Active Comparator group

Description:

active drug

Treatment:

Drug: propofol

dexmedetomidine

Active Comparator group

Description:

sedative

Treatment:

Drug: dexmedetomidine

midazolam

Active Comparator group

Description:

Sedative

Treatment:

Drug: Midazolam

placebo

Placebo Comparator group

Description:

placebo control

Treatment:

Drug: saline placebo