The Effect of Sevoflurane on Airway Hyperreactivity During the Perioperative Period.

China Medical University

Status: Completed

Conditions: General Anesthesia; RSV Infection in Children Less Than 5 Years of Age

Treatments: Drug: Sevoflurane (Volatile Anesthetic); Drug: propofol

Study type: Observational

Funder types: Other

Identifiers

NCT06694675

FirstHCMU-sevoflurane

Details and patient eligibility

About

To investigate the effects of sevoflurane on respiratory parameters and respiratory inflammation in healthy and RSV-infected under general anesthesia and to propose suitable perioperative airway protection measures for children with respiratory virus infection undergoing general anesthesia.

Enrollment: 97 patients

Sex: All

Ages: 2 to 5 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Patients voluntarily joined this study and signed an informed consent form；
2. Age: 2-5 years old；
3. The patient should have a good general condition and no serious internal medicine comorbidities (ASA classification of the American Anesthesiology Association is Grade I); BMI ≤ 20;
4. Plan to undergo elective adenoidectomy or adenotonsillectomy with tracheal intubation.

Exclusion criteria

1. Children with a history of allergic asthma;
2. Children with space-occupying lesions of the chest and lungs, or acute bronchiolitis or pneumonia;
3. Children with cardiovascular diseases that may cause cough, wheezing, and other symptoms;
4. Children who used leukotriene modulators, β2 receptor agonists, anticholinergics, theophyllines, or hormonal treatment drugs within two weeks;
5. Children allergic to propofol, sevoflurane, or other anesthetic agents;
6. Children with a family history of malignant hyperthermia;
7. Children with liver and kidney dysfunction;
8. The result of rapid antigen detection and nucleic acid test for RSV was inconsistent, or children combined with pathogen infections other than RSV;
9. Children with fever.

Trial design

97 participants in 2 patient groups

Control group

Description:

The nasopharyngeal swab test for RSV antigen was negative for patients with no history of respiratory infection in the past six weeks before surgery.

Treatment:

Drug: propofol

Drug: Sevoflurane (Volatile Anesthetic)

RSV group

Description:

The nasopharyngeal swab of the RSV antigen test is positive.

Treatment:

Drug: propofol

Drug: Sevoflurane (Volatile Anesthetic)