The Effect of Sevoflurane on Haemodynamics

Fudan University

Status: Completed

Conditions: Cardiac Output; Venous Return; Vascular Resistance; Sevoflurane

Study type: Observational

Funder types: Other

Identifiers

NCT06707077

HL-002-2024

Details and patient eligibility

About

Cardiac output (CO) is measured using Mostcare. Mean systemic filling pressure (MSFP) and vascular resistances are calculated using venous return curves constructed by measuring steady-state arterial and venous pressures and cardiac output (CO) during inspiratory hold manoeuvres at increasing plateau pressures. Measurements are performed at three incremental levels of targeted sevoflurane concentrations.

Full description

Tracheal intubation is performed after anesthesia induction with sevoflurane. Radial arterial is cannulated and pressure transducer is connected to MostCare (core technique PRAM). HR, MAP, CVP, CO, SVR, PPV, and dp/dt are recorded at three incremental levels of targeted sevoflurane concentrations. MSFP and vascular resistances are calculated.

Enrollment: 40 patients

Sex: All

Ages: 3 to 10 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Association of Anesthesiologists (ASA)physical status score I-III
• major elective surgery that dictates the use of invasive hemodynamic monitoring including CVP and continuous arterial blood pressure monitoring.

Exclusion criteria

• symptomatic peripheral vascular disease or pulmonary disease
• aberrant cardiovascular anatomy
• significant valvular regurgitation
• severe arrhythmia

Trial design

40 participants in 1 patient group

Exposure

Description:

The patient receives three increasing target end-tidal concentrations of sevoflurane, depending on what is hemodynamically (i.e. arterial hypotension) feasible in the individual patient.