The Effect of Sevoflurane Versus Isoflurane on Vasopressor Need (ESIVAN)

UMC Utrecht

Status and phase

Terminated

Phase 4

Conditions

Hypotension

Treatments

Drug: Sevoflurane and isoflurane

Study type

Interventional

Funder types

Other

Identifiers

NCT00922844

NL24375.041.08

Details and patient eligibility

About

Aim of this study is to determine the effect of isoflurane versus sevoflurane on blood pressure and systemic vascular resistance.

Full description

In modern anesthesia a variety of volatile anesthetics is available. In cardiac anesthesiology both isoflurane and sevoflurane are frequently used. At present the number of studies comparing the influence of isoflurane and sevoflurane on blood pressure and systemic vascular resistance is limited. Moreover, the results presented in the available literature are inconsistent. The decision as to which of both volatiles should be used during cardiac surgery is not evidence-based, but is based on personal preference of the anesthesist. The most reliable way to compare the effects of isoflurane and sevoflurane on blood pressure and systemic vascular resistance is a randomized controlled trial in patients during Cardiopulmonary bypass (CPB).

Enrollment

10 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

competent adult patients (18 years or older)undergoing elective coronary artery bypass grafting with the use of the cardiopulmonary bypass.

Exclusion criteria

Patients undergoing valve surgery or combined surgical procedures (e.g. coronary artery bypass grafting in combination with valve reconstruction.
uncontrolled hypertension
a poor left ventricular function
renal failure
a body mass index of > 25
history of cerebrovascular accident, transient ischemic accident or carotid artery stenosis.