The Effect of Short-term L-citrulline Supplementation on Blood Pressure and Arterial Stiffness

European University Cyprus

Status: Completed

Conditions: Blood Pressure

Treatments: Dietary Supplement: L-Citrulline; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT05974813

EUC_cit

Details and patient eligibility

About

The goal of this clinical trial is to examine the effect of short-term L-Citrulline on central and peripheral blood pressure in healthy older adults. The main questions it aims to answer are:

• Does L-citrulline favorably affect blood pressure at rest and during exercise?
• Does L-citrulline favorably affect arterial stiffness?
• Does L-citrulline favorably affect muscle oxygenation at rest and during exercise?

Participants will be asked to consume L-citrulline and a placebo for six days and participate in the evaluation of their blood pressure, arterial stiffness, and muscle oxygenation before and after each intervention.

Researchers will compare L-citrulline and placebo groups to examine whether L-citrulline supplementation affects the above health parameters.

Enrollment: 12 patients

Sex: Male

Ages: 55 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• subject provides written informed consent.
• normal health profile.

Exclusion criteria

• history of musculoskeletal injury in the legs during the previous six months.
• smoker.
• consumption of any medication the last three months.
• consumption of any nutritional supplement the last three months.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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12 participants in 2 patient groups, including a placebo group

L-Citrulline

Experimental group

Description:

Participants will receive 6 g (3 g every 12 h) of L-citrulline (Now, L-citrulline Pure Powder) for six-days.

Treatment:

Dietary Supplement: L-Citrulline

Placebo

Placebo Comparator group

Description:

Participants will receive 6 g (3 g every 12 h) of maltodextrin (Now, Maltodextrin) for six-days.

Treatment:

Dietary Supplement: Placebo