The Effect Of Simvastatin On Bone Remodeling In Socket Of Mandibular Teeth

Hadassah Medical Center

Status: Unknown

Conditions: Hypercholesterolemia

Treatments: Drug: Simvastatin

Study type: Interventional

Funder types: Other

Identifiers

NCT01085149

h123-HMO-CTIL

Details and patient eligibility

About

Simvastatin has been reported to promote osteoblastic activity and inhibit osteoclastic activity by enhancing the expression of BMP2. There have been many studies demonstrating the bone-promoting effect of local application various animal models including after application into socket of teeth in a rat. the purpose of the study is to investigate the effect of slow release topical simvastatin in socket of mandibular teeth on bone remodeling in the socket

Full description

after extraction of mandibular single root teeth 10 mg of slow release simvastatin would be inserted to the socket. observation will be at 1 week, 4 weeks and 3 months.after 3 months the patients will have dental CT as done routinely in our clinic before placing dental implants and the bone density and height will be measured on this data. during the procedure of inserting a dental implant a trephine will be taken for histology.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• need extraction of single root tooth
• intend to have prosthetic implant in place of extraction

Exclusion criteria

• treated with simvastatin P.O for hypercholesterolemia

Trial design

20 participants in 2 patient groups

study group

Experimental group

Description:

simvastatin will be inserted to sockets

Treatment:

Drug: Simvastatin

control

No Intervention group

Description:

sockets will be left to healing without material in socket

Treatment:

Drug: Simvastatin