The Effect of Sitting and Moderate Exercise on Plasma Triglyceride Elevation After a Meal

The University of Texas System (UT)

Status: Completed

Conditions: Atherosclerosis; Metabolic Syndrome

Treatments: Behavioral: Prolonged sitting without exercise; Behavioral: Prolonged sitting with exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03098446

2016-12-0022

Details and patient eligibility

About

The purpose of this study is to investigate the effect of 4 days of sitting and moderate exercise on plasma triglyceride elevation after a meal.

Full description

Subjects will undergo three weeks (two intervention, one washout) of testing during which they will participate in two conditions: 1) prolonged sitting (~14-hours/day) with a 1-hour bout of acute exercise at 65% of pre-intervention VO2max and 2) prolonged sitting (~14-hours/day) without an acute bout of exercise. During each intervention week, subjects will have 2 days of dietary and activity control, followed by 4 days during which prolonged sitting will occur. On the evening of the 4th day, subjects in the exercise group will perform the acute bout of exercise. On day 5, all subjects will undergo a lipid tolerance test to determine the body's ability to clear triglycerides from the blood as well as insulin/glucose response and substrate oxidation. Blood samples will be assayed for the previously mentioned substances and postprandial gas collection will be analyzed via indirect calorimetry.

Enrollment: 10 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Exclusion criteria

• cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.)
• respiratory problems
• musculoskeletal problems that prevent prolonged sitting or exercise
• obesity
• susceptibility to fainting

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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10 participants in 2 patient groups

Prolonged sitting with exercise

Experimental group

Description:

Subjects will be asked to undergo prolonged sitting (\~14-hours/day) for 4 days. On the evening of day 4, they will be asked to run at 65% of VO2max for 1-hour.

Treatment:

Behavioral: Prolonged sitting with exercise

Prolonged sitting without exercise

Experimental group

Description:

Subjects will be asked to undergo prolonged sitting (\~14-hours/day) for 4 days. Subjects will not be asked to complete the acute bout of exercise to serve as a control.

Treatment:

Behavioral: Prolonged sitting without exercise