The Effect of Smoking and Non-surgical Periodontal Treatment on Gingival Crevicular Fluid Cyclophilin A and EMMPRIN Levels

Ege University

Status: Completed

Conditions: Periodontitis; Smoking; Non-surgical Periodontal Treatment

Treatments: Procedure: non-surgical periodontal treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT04430764

2014/Diş/019

Details and patient eligibility

About

This study aimed to investigate the effect of smoking and non-surgical periodontal treatment on gingival crevicular fluid CyPA and EMMPRIN levels in patients with periodontitis. Twenty-eight patients with periodontitis (14 non-smoker and 14 smoker) and 30 control subjects (15 non-smoker and 15 smoker) were included into the study. Non-surgical periodontal treatment was applied to all periodontitis patients. Periodontal parameters and GCF CyPA and EMMPRIN levels were evaluated during 3 months following non-surgical periodontal treatment. GCF CyPA and EMMPRIN levels were analyzed by ELISA.

Enrollment: 58 patients

Sex: All

Ages: 29 to 61 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• generalized periodontitis with stage III-IV & Grade B
• no systemic and periodontal diseases
• smokers (minimum 10 cigarettes per day for at least ten years)
• non-smokers (never smoked)

Exclusion criteria

• Systemic diseases
• Infectious diseases
• Pregnancy or lactating
• Having periodontal treatment during the last 6 months
• Having antibiotic treatment within the past 3 months
• Former smokers

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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58 participants in 2 patient groups

smoker

Experimental group

Treatment:

Procedure: non-surgical periodontal treatment

non-smoker

Active Comparator group

Treatment:

Procedure: non-surgical periodontal treatment