The Effect of Smoking on Thermoregulation

Sheba Medical Center

Status: Completed

Conditions: Cigarette Smoking

Treatments: Drug: Nicotine; Other: cigarette smoking

Study type: Interventional

Funder types: Other

Identifiers

NCT01596556

SHEBA-11-8767-AD-CTIL

Details and patient eligibility

About

To the best of our knowledge, a possible relation between smoking and heat injuries or heat intolerance was never scientifically examined, although such a relation is logical according to the observations that smoking has a thermogenic effect, decreases physical fitness and affects the body's heat dissipation.16 healthy young male volunteers will participate in the study, 8 smokers and 8 non-smokers. They will arrive to our lab four or six times. They will perform VO2 test and heat tolerance test (HTT) in different conditions.

Full description

16 healthy young male volunteers will participate in the study, 8 smokers and 8 non-smokers. They will arrive to our lab four or five times. During their first visit they will go through a VO2 max test in order to evaluate their aerobic fitness, and their physiological efficiency. During their second visit all subjects will go through the same test after exposure to nicotine. During the smokers' third visit they will go through the same test, after exposure to cigarette smoking. During the non-smokers third visit and the smokers fourth visit - they will go through an exercise heat tolerance test without prior smoking. During the fifth visit the smokers will go through an exercise heat tolerance test after exposure to cigarette smoking. During the smokers' sixth visit and the non-smokers fourth visit they will go through an HTT after exposure to nicotine.

Enrollment: 16 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 18-30
• healthy
• after medical checkup
• after signing concent form
• for the smokers: smoking 0.5-1.5 packs of cigarettes a day at least 2 years.

Exclusion criteria

• heart disease
• respiratory disease
• baseline bp above 140/90 mmHg
• diabetes
• anhydrosis
• skin disease
• acute illness
• detoxification from nicotine
• allergy to nicotine
• smoking other then specified in the inclusion criteria

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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16 participants in 2 patient groups

smokers

Experimental group

Description:

This arm consists of smokers.

Treatment:

Drug: Nicotine

Other: cigarette smoking

non-smokers

Active Comparator group

Description:

non-smoking participants in the study

Treatment:

Drug: Nicotine