The Effect of Spironolactone on Pain in Older People With Osteoarthritis (SPIR-OA)

University of Dundee

Status and phase

Completed

Phase 4

Conditions

Osteoarthritis, Knee

Treatments

Drug: spironolactone

Study type

Interventional

Funder types

Other

Identifiers

NCT02046668

13/WS/0232

2013-002638-19 (EudraCT Number)

Details and patient eligibility

About

This pilot study will obtain preliminary evidence on which to base sample size calculations for a future trial of whether spironolactone (an aldosterone blocker) reduces knee pain in older people with symptomatic OA knee when given in addition to usual analgesia. Aldosterone is known to be pro-inflammatory, and spironolactone suppresses cytokine production in chronic arthritis. This application builds on previous work by the applicants showing that spironolactone significantly improved quality of life (particularly pain) in frail older people. The investigators will recruit 86 people (aged 70 years or over) with well-defined OA knee to 25mg spironolactone daily or to matching placebo for 12 weeks. The primary outcome is the between group difference in change in WOMAC pain sub-score at 12 weeks. Secondary outcomes are the WOMAC stiffness and physical function subscales and health related quality of life (EQ-5D). Morning cortisol levels will be measured to assess the effect of mineralocorticoid receptor blockade on glucocorticoid levels, which may mediate the anti-inflammatory effect of spironolactone; and urinary CTX-II, and serum matrix metalloproteinase-3 (MMP-3) will be measured as biomarkers as both are sensitive to the effects of pharmacological interventions for osteoarthritis.

Enrollment

86 patients

Sex

All

Ages

70+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Participant is willing and able to give informed consent
Community dwelling
Aged 70 years and over
Symptomatic idiopathic OA knee according to American College of Rheumatology clinical and radiographic criteria (ie Knee pain - with or without crepitus and presence of osteophytes on x ray)
To avoid floor effects, participants will require to have moderate (or more severe) pain at screening in at least 2 out of 5 WOMAC pain score items
To have been in receipt (prescription or/and over the counter) of one or more analgesic agents at a therapeutic dose for at least 2 months
Willing to have knee x-ray if one has not been taken in preceding 12 months

Exclusion criteria

Clinical diagnosis of symptomatic heart failure
History of inflammatory arthritis
Already taking spironolactone
Previous intolerance to spironolactone
Known allergies to spironolactone or lactose
Objection to taking capsules made from animal sourced gelatine
Taking oral NSAIDs (because of the increased risk of renal impairment when combined with spironolactone)
Taking ACE inhibitors or ARBs (angiotensin II receptor antagonists). ARBs have many properties similar to those of ACE inhibitors. Both will be exclusion because of the increased risk of acute kidney injury and hyperkalaemia, and because our previous study also excluded those on ACE inhibitors (and ARBs) and treatment was safe and well tolerated.
Supine hypotension (supine systolic blood pressure <100mmHg at screening)
Significant chronic kidney disease (eGFR<40ml/min)
Serum sodium<130mmol/l
Serum potassium>5.0mmol/l
Symptomatic orthostatic hypotension (measured at screening)
Nursing home resident
Wheelchair bound
Participating in another clinical trial (other than observational trials and registries) concurrently or within 30 days prior to screening for entry into this study
Known contraindication to spironolactone therapy
Participant who is terminally ill, defined as less than 3 months expected survival