The Effect of Spontaneous Respiration on Pulse-oximetry Measurements

Universidad Autonoma de Nuevo Leon

Status: Unknown

Conditions: Chronic Respiratory Disease; COPD; Interstitial Lung Disease

Treatments: Procedure: Deep breaths

Study type: Interventional

Funder types: Other

Identifiers

NCT04139356

UAutonomaNL

Details and patient eligibility

About

This is a study designed to measure, characterize and describe changes on pulse-oxymetry values produced as a result of deep breaths in patients with stable chronic hypoxemic respiratory failure.

Full description

There is no standard way of measuring rest pulse-oxymetry in terms of depth of respiration. Rest pulse-oxymetry values are used in the clinical setting to make therapeutic decisions regarding the need of supplemental oxygen. The primary goal of this study is to measure the change of pulse-oxymetry values during an experimental protocol of 10 deep breaths during one minute in patients with chronic hypoxemia. 45 patients will be studied in this first phase. In a second phase, secondary goals will be to measure Vd/Vt vent, noninvasive cardiac output and CT densitometry during the same deep breaths protocol in a subset of 13 patients with the grater increase observed in the first phase of study.

Enrollment: 45 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with chronic lung disease causing rest hypoxemia, with rest SpO2 values equal or lower than 94% on room air
• Ambulatory patients capable of performing 6 min walking test
• Patients older than 18 years old.

Exclusion criteria

• Patients with significant collagen disease causing Raynaud phenomenon.
• Patients with hypothermia lower than 35 degrees Celsius
• Patients with rest SpO2 values equal or lower than 80% on room air
• Patients unable to perform PFTs
• Patients unable to complete 6 min walking test without supp O2.
• Patients unable to perform experimental deep breaths on CT scan

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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45 participants in 1 patient group

Patients with rest O2 desaturation

Experimental group

Description:

Patient will undergo an experimental protocol consisting of 10 deep inspirations to measure and characterize changes on pulse-oxymetry values

Treatment:

Procedure: Deep breaths