The Effect of Statins in Patients With Chronic Obstructive Pulmonary Disease (COPD)

University of Nottingham

Status and phase

Completed

Phase 4

Conditions

Chronic Obstructive Pulmonary Disease

Treatments

Drug: Lactose tablet

Drug: Simvastatin

Study type

Interventional

Funder types

Other

Identifiers

NCT01151306

09105

Details and patient eligibility

About

Chronic obstructive pulmonary disease (COPD) is a condition of the lungs which results in breathing difficulties due to the lungs becoming inflamed and the airways narrowed. Current treatments have focused on opening up the narrowed airways but, in addition, we know there is increased inflammation in the blood and these patients are at increased risk of heart disease. Statins, simvastatin being one of them, are drugs used to lower cholesterol in the blood but may also reduce inflammation and lower the risk of heart disease. This study will explore whether simvastatin reduces one of the risk factors in patients with COPD in a short term proof of principle study. The key purpose is to determine whether simvastatin improves the pressure and stiffness of the main blood vessels namely the arterial stiffness measure of aortic pulse wave velocity (PWV). In parallel, we will describe changes in airways and / or blood inflammation and change in breathing ability

Enrollment

70 estimated patients

Sex

All

Ages

45 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male or female patients aged 45-80 years;
Confirmed COPD: FEV1 30-80% predicted, FEV1/FVC<0.7, salbutamol reversibility <12%, supportive smoking history
If female of childbearing potential, have a negative serum pregnancy test at screening and use a medically acceptable form of contraception starting at screening and continuing throughout the study (defined as an oral contraceptive, or barrier method combined with a spermicide)
Able to attend for regular clinic appointments
In opinion of investigator, the patient will be able to comply with the requirements of the protocol
Provide written informed consent.

Exclusion criteria

Known hypersensitivity to or side effects relating to previous statin treatment, or current therapy which includes a statin, ezetimibe or fibrate
Clinically significant liver function abnormality; alcohol excess
Hypercholesterolaemia > or equal to 6.5mmol/L
Females who are pregnant, breast feeding, or at risk of pregnancy and not using a medically acceptable form of contraception.
Any condition judged by investigator that would cause the study to be detrimental to patient.
Conditions: rheumatoid disease/other collagen vascular disease requiring therapy; diabetes mellitus; untreated hypothyroidism; inflammatory bowel disease; other respiratory disease; known alpha 1 antitrypsin deficiency; malignancy; documented history of ischaemic heart disease (IHD); cor pulmonale or known congestive heart failure; patients planning to undergo elective surgery during the study period.
Exacerbation in the last 4 weeks.
Significant hypoxia (PaO2 <7.3kPa)
Known lactose intolerance.
Therapies: oral prednisolone for more than 1 week in the last 6 months; disease modifying drugs (Gold/ sulphasalazine etc); weight losing drugs; concomitant use of warfarin, cyclosporine; concomitant administration of potent CYP3A4 inhibitors (e.g. itraconazole, ketoconazole, HIV protease inhibitors, erythromycin, clarithromycin, telithromycin and nefazodone). Use of any investigational drug within four weeks of the baseline visit.