The Effect of Stevia Rebaudiana Extracts on Different Variables Related to Caries: an in Vitro and in Vivo Evaluation.

Università degli Studi di Sassari

Status and phase: Completed; Phase 2

Conditions: Dental Caries

Treatments: Dietary Supplement: Effect of Stevioside and Rebaudioside on plaque pH

Study type: Interventional

Funder types: Other

Identifiers

NCT01757990

SS_2012_10

Details and patient eligibility

About

The aim of the present investigation was to evaluate the effect of stevioside and rebaudioside on several variables related to caries development. Two approaches were performed: an in vitro evaluation of the growth of a culture of mutans streptococci and in vivo randomized study on the effect of a single rinse containing stevioside and rebaudioside on plaque-pH.

Enrollment: 20 patients

Sex: All

Ages: 20 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

good general health, normal salivary secretion rate, normal buffer capacity

Exclusion criteria

systemic diseases, salivary secretion reduction, reduced buffer capacity

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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20 participants in 3 patient groups

Stevioside extract

Experimental group

Description:

After measuring baseline plaque pH, the subjects rinsed for 1 minute with the solution containing Stevioside extract. Plaque pH was then measured at 5, 10, 15, 30, 45 and 60 min after the mouth rinse.

Treatment:

Dietary Supplement: Effect of Stevioside and Rebaudioside on plaque pH

Rebauside extract

Experimental group

Description:

After measuring baseline plaque pH, the subjects rinsed for 1 minute with the solution containing Rebaudioside extract. Plaque pH was then measured at 5, 10, 15, 30, 45 and 60 min after the mouth rinse.

Treatment:

Dietary Supplement: Effect of Stevioside and Rebaudioside on plaque pH

Saccarosio

Sham Comparator group

Description:

After measuring baseline plaque pH, the subjects rinsed for 1 minute with the sucrose solution. Plaque pH was then measured at 5, 10, 15, 30, 45 and 60 min after the mouth rinse.

Treatment:

Dietary Supplement: Effect of Stevioside and Rebaudioside on plaque pH