The Effect of Succinylated Gelatin on the Blood Viscosity and Oxygen Delivery

Sun Yat-sen University

Status and phase: Unknown; Phase 4

Conditions: Blood Viscosity

Treatments: Drug: Succinylated gelatin; Drug: Ringer's lactate solution

Study type: Interventional

Funder types: Other

Identifiers

NCT02631356

2015[22]

Details and patient eligibility

About

The study is to investigate the effect of succinylated gelatin on the blood viscosity and oxygen delivery in patients during surgeries, so as to have a better understanding of the safety in the use of succinylated gelatin for surgical patients.

Enrollment: 12 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients between the ages of 18 years and 60 years
• ASA physical status I and II
• surgical procedures requiring general anesthesia with continuous CVP and arterial pressure monitoring

Exclusion criteria

• Patients younger than 16 y or older than 60 y
• Body Mass Index (BMI) <18 or >30
• Allergy to any of the drugs used
• Severe cardiovascular dysfunction
• Patient refusal

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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12 participants in 2 patient groups, including a placebo group

Ringer's lactate solution

Placebo Comparator group

Description:

Infusion of Ringer's lactate solution (10ml/kg) in the control group

Treatment:

Drug: Ringer's lactate solution

Succinylated gelatin

Active Comparator group

Description:

Infusion of Succinylated gelatin (10ml/kg) in the test group

Treatment:

Drug: Succinylated gelatin