The Effect of Sucrose on Pain Relief During Venous Blood Sampling in Preterm Infants

Norwegian University of Science and Technology

Status: Completed

Conditions: Pain

Treatments: Other: 0.5 ml sucrose 25%; Other: 0.2 ml sucrose 25%

Study type: Interventional

Funder types: Other

Identifiers

NCT02344368

2014/2089

Details and patient eligibility

About

Despite the fact that oral sucrose is the most frequently studied non-pharmacological intervention for procedural pain relief in infants, there is a paucity of data on the minimal effective dose. The aim of this study is to find the minimal effective dose of sucrose to reduce pain during a single venous blood sampling procedure.

Enrollment: 50 patients

Sex: All

Ages: Under 8 weeks old

Volunteers: No Healthy Volunteers

Inclusion criteria

• born preterm
• more than 1000 gram

Exclusion criteria

• severe intraventricular hemorrhage
• cerebral malformations
• other malformations requiring surgery
• medication that may impair pain expression (opioids, paracetamol, sedatives)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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50 participants in 2 patient groups

0.2 ml sucrose

Experimental group

Description:

on 2 occasions within 1 week 0.2 ml sucrose 25% or 0.5 ml sucrose 25% will be given in randomized order to the same infant during blood sampling

Treatment:

Other: 0.5 ml sucrose 25%

Other: 0.2 ml sucrose 25%

0.5 ml sucrose

Experimental group

Description:

on 2 occasions within 1 week 0.2 ml sucrose 25% or 0.5 ml sucrose 25% will be given in randomized order to the same infant during blood sampling

Treatment:

Other: 0.5 ml sucrose 25%

Other: 0.2 ml sucrose 25%