The Effect of Sugammadex Given Based on Ideal, Actual or Adjusted Body Weight on Reversal of Rocuronium.

Ain Shams University

Status: Completed

Conditions: Muscle Relaxation

Treatments: Drug: Sugammadex

Study type: Interventional

Funder types: Other

Identifiers

NCT03381209

FMASU R 39/2017

Details and patient eligibility

About

The aim of this study is compare the reversal of rocuronium induced neuromuscular blockade in morbidly obese patients using three doses of sugammadex; based on ideal body weight, adjusted body weight, and actual body weight.

Full description

The aim of this study is compare the reversal of rocuronium induced neuromuscular blockade in morbidly obese patients using three doses of sugammadex; based on ideal body weight, adjusted body weight, and actual body weight. Reversal Time: time from administration of Sugammadex to train of four (TOF) ratio ≥ 0.9 will be used as primary outcome.

Time need for extubation (time from administration of sugammadex to extubation), and duration of stay in post anesthesia care unit (PACU), will be used as secondary outcome.

Enrollment: 60 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients older than 18 years and under 45 years,
• body mass index ≥ 40 kg/m2, with indication of bariatric surgery

Exclusion criteria

• Patients with comorbid including: neuromuscular disease, renal impairment, and patients with difficult airway were excluded from this study.

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 3 patient groups

Group A

Experimental group

Description:

Sugammadex given in a dose of 2mg/kg based on ideal body weight

Treatment:

Drug: Sugammadex

Group B

Experimental group

Description:

Sugammadex given in a dose of 2mg/kg based on adjusted body weight

Treatment:

Drug: Sugammadex

Group C

Experimental group

Description:

Sugammadex given in a dose of 2mg/kg based on actual body weight

Treatment:

Drug: Sugammadex