The Effect of Supplementation of Vitamin D3 on Inflammation Induced by 100 km Running, Iron Metabolism and Erythropoiesis

Gdansk University of Physical Education and Sport

Status: Completed

Conditions: Ineffective Erythropoiesis; Healthy; Inflammation; Muscle; Iron Metabolism

Treatments: Other: placebo; Drug: Cholecalciferol

Study type: Interventional

Funder types: Other

Identifiers

NCT05880030

AWFiS/2022_2_MK

Details and patient eligibility

About

A group of runners received vitamin D (10,000 IU - international unit per day) for two weeks. The aim of the intervention was to check the effect of vitamin D supplementation on selected parameters of inflammation and iron metabolism in comparison with the placebo group. Blood was collected before and after supplementation. Next: before, after 25, 50, 75,100 km running and 12 hours after the run. The data were subjected to statistical analysis.

Full description

Subjects were randomized to two groups: the experimental one, n = 20 and the placebo one, n = 20 with the same age, experience in running and 25(OH)D level. The experimental group received vitamin D3 supplementation (around 10,000 UI/day, i.e., 20 droplets -Vigantol medicament, Merck) and the control group received a placebo (20 droplets of sunflower oil, placed in an identical bottle as vitamin D3) for two weeks before a run. The last vitamin D dose was taken 24 h before the 100 km ultra-marathon. 40 male athletes took part in the 100 km ultra-marathon. Blood was collected before (day 0) and after supplementation (day 14). Next (day 15): before, after 25, 50, 75,100 km running and 12 hours after the run (day 16). The data were subjected to statistical analysis.

Enrollment: 40 patients

Sex: Male

Ages: 28 to 64 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male
• athletes running ultra-marathons

Exclusion criteria

• vitamin D3 supplementation
• multivitamin and iron supplementation
• serum 25(OH)D low < 10 ng/mL
• serum 25(OH)D high > 100 ng/mL
• haemoglobin < 10 g/dL
• other (sports injury, tournament)

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups, including a placebo group

Vitamin D

Active Comparator group

Description:

Vigantol 10 000 IU/day (20 droplets) two weeks supplementation (vitamin D3)

Treatment:

Drug: Cholecalciferol

Control

Placebo Comparator group

Description:

sunflower oil, (20 droplets) two weeks supplementation.

Treatment:

Other: placebo