The Effect of Tea on Vascular Function and Insulin Sensitivity

Liverpool John Moores University

Status: Completed

Conditions: Insulin Resistance

Treatments: Dietary Supplement: Green tea; Dietary Supplement: Placebo tea

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02777853

Greenshield16

Details and patient eligibility

About

The aim of this research is to explore changes in peripheral/cerebrovascular function and insulin sensitivity after a 7-day combination of physical activity reduction (-50% steps per day) and overfeeding (+50% kcal per day, comprising 65% fat) in healthy male volunteers, and examine whether daily intake of tea can prevent such changes.

Full description

The aim of this study is to explore the impact of a 7-day 'unhealthy' lifestyle that combines physical activity reduction (-50% steps per day) and overfeeding (+50% kcal per day, comprising 65% fat) on peripheral (conduit artery and skin microvessels) and cerebrovascular function and insulin sensitivity in healthy male participants. Moreover, the investigators will explore whether the detrimental impact of this lifestyle can be mitigated by daily tea consumption (equivalent to 6 cups/day). To explore this hypothesis, the investigators will perform measurements of these parameters before and after 7-days of reduced physical activity and overfeeding, with and without the combination of daily tea ingestion.

Enrollment: 12 patients

Sex: Male

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged 18-55 years
• Male
• Habitually active (>8,000 steps/day)
• Healthy

Exclusion criteria

• Smokers
• Medical history of cardiovascular/metabolic disease
• Family history of cardiovascular disease (first degree relatives)
• On medication known to influence the cardiovascular system
• BMI of <18 or >30 kg/m2
• Known food allergies or special dietary requirements
• Vaccination (<1 week) due to induced systemic inflammatory reaction

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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12 participants in 2 patient groups, including a placebo group

Active (green) tea

Experimental group

Description:

Tea to be ingested 3 times per day for 7 days.

Treatment:

Dietary Supplement: Green tea

Placebo tea

Placebo Comparator group

Description:

Tea to be ingested 3 times per day for 7 days.

Treatment:

Dietary Supplement: Placebo tea