ClinicalTrials.Veeva

Menu

The Effect of Tea on Vascular Function and Insulin Sensitivity

L

Liverpool John Moores University

Status

Completed

Conditions

Insulin Resistance

Treatments

Dietary Supplement: Green tea
Dietary Supplement: Placebo tea

Study type

Interventional

Funder types

Other
Industry

Identifiers

NCT02777853
Greenshield16

Details and patient eligibility

About

The aim of this research is to explore changes in peripheral/cerebrovascular function and insulin sensitivity after a 7-day combination of physical activity reduction (-50% steps per day) and overfeeding (+50% kcal per day, comprising 65% fat) in healthy male volunteers, and examine whether daily intake of tea can prevent such changes.

Full description

The aim of this study is to explore the impact of a 7-day 'unhealthy' lifestyle that combines physical activity reduction (-50% steps per day) and overfeeding (+50% kcal per day, comprising 65% fat) on peripheral (conduit artery and skin microvessels) and cerebrovascular function and insulin sensitivity in healthy male participants. Moreover, the investigators will explore whether the detrimental impact of this lifestyle can be mitigated by daily tea consumption (equivalent to 6 cups/day). To explore this hypothesis, the investigators will perform measurements of these parameters before and after 7-days of reduced physical activity and overfeeding, with and without the combination of daily tea ingestion.

Enrollment

12 patients

Sex

Male

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Aged 18-55 years
  • Male
  • Habitually active (>8,000 steps/day)
  • Healthy

Exclusion criteria

  • Smokers
  • Medical history of cardiovascular/metabolic disease
  • Family history of cardiovascular disease (first degree relatives)
  • On medication known to influence the cardiovascular system
  • BMI of <18 or >30 kg/m2
  • Known food allergies or special dietary requirements
  • Vaccination (<1 week) due to induced systemic inflammatory reaction

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Double Blind

12 participants in 2 patient groups, including a placebo group

Active (green) tea
Experimental group
Description:
Tea to be ingested 3 times per day for 7 days.
Treatment:
Dietary Supplement: Green tea
Placebo tea
Placebo Comparator group
Description:
Tea to be ingested 3 times per day for 7 days.
Treatment:
Dietary Supplement: Placebo tea

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems