The Effect of Testosteron Replacement Treatment on the Fibroblast Growth Factor-23, Asymmetric Dimethylarginine and Vitamin D Levels in the Congenital Hypogonadotropic Hypogonadism

Gulhane School of Medicine

Status and phase: Completed; Phase 4

Conditions: Hypogonadism

Treatments: Drug: Testosterone

Study type: Interventional

Funder types: Other

Identifiers

NCT02111473

GSM-032014

Details and patient eligibility

About

The study is designed to answer the following questions:

1. What is the effect of testosteron replacement treatment on the endothelial dysfunction.

2/ What is the effect of testosteron replacement on the bone mineral metabolism.

Full description

this is an interventional study which is examine the effect of testosteron replacement treatment on the endothelial dysfunction and bone mineral metabolism in hypogonadotropic hypogonadal patients.

Enrollment: 49 patients

Sex: Male

Ages: 18 to 28 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Men
• Congenital hypogonadism
• Treatment Naive

Exclusion criteria

• Previous history of androgen replacement
• Hypertension
• Diabetes mellitus

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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49 participants in 1 patient group

testosterone

Other group

Description:

testosterone 250 mg injection per 3-4 weeks for 6 months

Treatment:

Drug: Testosterone