The Effect of the ALDH2 Gene Polymorphism on the Propofol Potency for Inducing Loss of Consciousness

Fudan University

Status: Unknown

Conditions: Propofol

Treatments: Drug: Propofol

Study type: Observational

Funder types: Other

Identifiers

NCT03762538

EAGLES (Other Identifier)

Details and patient eligibility

About

The aim of this study is to determine whether ALDH2 gene polymorphisms (G/G, G/A A/A) have effect on the potency of propofol.

Enrollment: 100 estimated patients

Sex: Male

Ages: 50 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA II

Exclusion criteria

• ASA III-IV
• OSAS
• hepatic and renal insufficiency

Trial design

100 participants in 2 patient groups

G/G group

Description:

Patients who are determined to be G/G genotype.

Treatment:

Drug: Propofol

G/A A/A group

Description:

Patients who are determined to be G/A or A/A genotypes.

Treatment:

Drug: Propofol