The Effect of the Combined Use of Naloxone and Tramacet on Postoperative Analgesia in the Elderly

Lawson Health Research Institute

Status and phase: Completed; Phase 4

Conditions: Arthroplasty

Treatments: Drug: tramacet

Study type: Interventional

Funder types: Other

Identifiers

NCT00665262

12177 (Other Identifier)

R-06-159

Details and patient eligibility

About

Ten patients 70 years and older having elective total hip/knee replacement surgery will be recruited to receive a continuous IV infusion of naloxone and oral tramacet for analgesia. Postoperative analgesia, satisfaction, side effects, need for rescure analgesia, and length of stay.

Enrollment: 10 patients

Sex: All

Ages: 70+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aged 70 years or older able to give consent able to communicate in English having elective hip/knee arthroplasty ASA physical status 1-3

Exclusion criteria

• allergies to any of the following: naloxone, tramacet, NSAIDs, sulpha, or local anesthesic contraindication to spinal anesthesia contraindication to use of tramacet or celebrex ASA physical status4 chronic opiod use chronic pain syndrome

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

1

Experimental group

Description:

comibined use of tramacet and naloxone infusion perioperatively

Treatment:

Drug: tramacet