The Effect of the Multispecies Probiotic Ecologic 825 Versus Placebo in Ulcerative Colitis Patients (CUPIDO)

Wageningen University

Status

Suspended

Conditions

Ulcerative Colitis

Treatments

Dietary Supplement: Ecologic 825

Dietary Supplement: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT02361957

NL46674.081.13

Details and patient eligibility

About

RATIONALE: The underlying etiology in inflammatory bowel diseases such as Ulcerative Colitis is not yet fully understood. Studies suggest a relation between higher intestinal permeability and aberrant changes of the epithelium. Dysbiosis of the intestinal microbiota might be the cause. Probiotics may restore the balance of the intestinal microbiota. In theory this could improve intestinal permeability and therefore reduce disease activity and maintain remission in patients with Ulcerative Colitis.

OBJECTIVE: To investigate whether a specifically designed multispecies probiotic mixture (ecologic 825®), as adjuvant therapy, can contribute to an improvement of intestinal permeability, microbiota composition, disease activity and inflammatory markers in ulcerative colitis.

STUDY DESIGN: 12-wk placebo-controlled randomized double-blind intervention with 2 parallel arms.

STUDY POPULATION: Adults diagnosed with left sided Ulcerative Colitis or Pancolitis in remission or mild stage of the disease. For inclusion of the patients the Patient Simple Clinical Colitis Activity Index (P-SCCAI) will be used.

INTERVENTION: Patients will receive either two daily dosages of 3 g of Ecologic® 825 or two daily doses of 3 g of the placebo, containing only the carrier material (both produced by Winclove Probiotics).

MAIN STUDY PARAMETERS/ENDPOINTS: Main study parameter is intestinal permeability measured by several techniques: the lactulose/mannitol absorption test (L/M test), LPS levels in blood serum and faecal zonulin. Secondary, inflammation will be measured from faecal calprotectin and blood c-reactive protein (CRP) levels. Furthermore samples will be stored to measure cytokine concentrations in serum and to analyse the microbial composition of the faecal samples using the HITchip. For the disease related quality of life the irritable bowel disease questionnaire (IBD-Q) and SF-36 will be used. All parameters will be measured at three time points; t=0, t=6 and t=12 weeks.

Enrollment

40 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Diagnosed Ulcerative Colitis (left sided UC or pancolitis)
Age 18-65 (because microbiota change at older age)
Stable disease activity (clinical remission with CRP levels <10mg/L and calprotectin <100 ug/g) as measured at baseline
Mild disease activity (P-SCCAI <5)
Mesalazine medication as only medication for UC with a maximum intake of 2.4 g/day

Exclusion criteria

History of intestinal surgery that might interfere with the outcome of the study
Diabetes Mellitus (medication dependent)
Current use of antibiotics
Current use of corticosteroids (30 days prior to the first baseline measurement).
Treatment with other medication besides mesalazine (NSAIDs, topical or systemic steroids, immunosuppressive drugs or aspirin) one week prior the first baseline measurement.
Use of other pre- and probiotics and not willing to stop these 2 weeks before the intervention period
Hypersensitivity or allergy to milk protein, soy protein and gluten
Alcohol abuse (male more than 14 servings a week, female more than 7 servings a week)
Female patients: currently pregnant or breast-feeding or intending to become pregnant during the study
Patients foreseen to need GI surgery during the study period
Patients with a history of cancer