The Effect of Thoracic Epidural Anesthesia With Different Block Level on Propofol Induction

China Medical University

Status and phase: Completed; Phase 4

Conditions: Thoracic Epidural Anesthesia; Gastrointestinal Surgery; Target Controlled Infusion (TCI); Block Level

Treatments: Drug: 0.9% normal saline; Drug: 2% lidocaine; Drug: 1% lidocaine

Study type: Interventional

Funder types: Other

Identifiers

NCT02135016

20140415

Details and patient eligibility

About

It is a prospective, randomized, placebo-controlled study to investigate the effect of TEA with different block level on propofol concentration during general anesthesia induction.

Enrollment: 45 patients

Sex: All

Ages: 40 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) I-II physical status,
• aged 40-60 yr,
• BMI 19-25 kg/m2,
• undergoing elective gastrointestinal surgery

Exclusion criteria

• patients with cardiovascular or neurological disease, drug or alcohol abuse and absolute contraindications for neuraxial blockade.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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45 participants in 3 patient groups, including a placebo group

1% lidocaine

Experimental group

Description:

epidural anesthesia with 1% lidocaine 10ml before propofol TCI

Treatment:

Drug: 1% lidocaine

2% lidocaine

Experimental group

Description:

epidural anesthesia with 2% lidocaine 5ml before propofol TCI

Treatment:

Drug: 2% lidocaine

0.9% normal saline

Placebo Comparator group

Description:

epidural anesthesia with 0.9% normal saline 5ml before propofol TCI

Treatment:

Drug: 0.9% normal saline