The Effect of Thyroid Antibodies on Female Reproductive Function and Pregnancy Outcomes

Zhejiang University

Status: Unknown

Conditions: Thyroiditis, Autoimmune

Treatments: Drug: LT4

Study type: Observational

Funder types: Other

Identifiers

NCT04952012

2020-678

Details and patient eligibility

About

Some women at reproductive age have positive antithyroid antibodies (ATAs). Thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) are the most common ATAs. This study aimed to evaluate the impact of ATAs on maturation of women reproductive system and pregnancy outcomes.

Enrollment: 4,000 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age during 18-45y;
• Women tested for TPOAb and/or TgAb, TSH, free T3, free T4, total T3 and total T4 during the 1st trimester of pregnancy

Exclusion criteria

• Multiple pregnancies;
• Age < 18 y or > 40 y;
• L-T4 or PTU intervention before pregnancy;
• Other autoimmune diseases.

Trial design

4,000 participants in 2 patient groups

ATA-positive

Treatment:

Drug: LT4

ATA-negative

Treatment:

Drug: LT4