The Effect of Transcatheter Ventricular Septal Defect Closure on Heart Rate Variability Parameters

Kayseri City Hospital

Status

Completed

Conditions

Autonomic Nervous System Imbalance

Closure; Interventricular Septum

Ventricular Septal Defect

Treatments

Diagnostic Test: 24 hours ambulatory Holter monitoring

Study type

Observational

Funder types

Other

Identifiers

NCT04859036

2014/39

Details and patient eligibility

About

In this study; we evaluated the heart rate variability parameters of pediatric patients whose VSDs were closed with the transcatheter method before and after, and compared with the control group.

Full description

Heart rate variability (HRV) is a sign of cardiac autonomic nervous system. Evaluation of HRV in pediatric ventricular septal defect (VSD) cases before and after transcatheter closure will enlighten us in terms of cardiac autonomic control.

Methods: 19 VSD cases treated with transcatheter closure method and 18 healthy children were enrolled in the study. 24 hours Holter rhythm monitorization was applied to all patients before closure of VSD and to the control group. In the patient group, Holter rhythm monitorization was repeated in the third months. HRV parameters were obtained from Cardio Scan Premier 12® program. Frequency domain (Total power, VLF, LF, HF, LF/HF ratio) and time domain analysis (SDNN, SDANN, SDNNi, pNN50, rMSSD) were applied.

Enrollment

37 patients

Sex

All

Ages

56 to 136 months old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

VSD diameter <6mm
Significant left-to-right shunt
Left atrial and ventricular enlargement detected by echocardiography or calculation of Qp/Qs ratio above 1.5 in the catheterization laboratory (Qp/Qs>1.5)

Exclusion criteria