The Effect of Transcranial Direct Current Stimulation (tDCS) on Depression in PD

Inje University

Status: Unknown

Conditions: Parkinson's Disease

Treatments: Device: transcranial direct current stimulation (tDCS)

Study type: Interventional

Funder types: Other

Identifiers

NCT03227783

17-0051

Details and patient eligibility

About

Depression is common in Parkinson's disease (PD), but the effective treatment is not established yet. tDCS is a non-invasive brain stimulation to modulate brain function. The tDCS on the depression in general population were already conducted, but not in PD. This study is to know whether transcranial direct current stimulation (tDCS) is effective for the treatment of depression in PD. Participant will be asked to visit three consecutive days for the non-invasive stimulation.

Enrollment: 26 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• UK Parkinson's disease brain bank criteria
• more than 19 years old
• Able to provide consent for the protocol
• Depression (based on DSM-IV criteria)

Exclusion criteria

• Dementia
• Unpredictable symptom fluctuations
• Contraindication to tDCS (i) irritations, cuts, lesions in the brain (ii) any preexisting unstable medical conditions, or conditions that may increase the risk of stimulation such as uncontrolled epilepsy (iii) history of severe cranial trauma with alteration of the cranial anatomy or metallic intracranial implants (iv) history of seizure
• Subjects without the capacity to give informed consent
• If participation in the study would, in the opinion of the investigators, cause undue risk or stress for reasons such as excessive fatigue, general frailty, or excessive apprehension

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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26 participants in 2 patient groups

Real tDCS

Active Comparator group

Description:

* Constant weak electric currents through scalp via two electrodes will be delivered. * Current intensity: 2mA, 20min/day

Treatment:

Device: transcranial direct current stimulation (tDCS)

Sham tDCS

Sham Comparator group

Description:

* a 1 mA current, for 30 s giving an initial sensation of tDCS while minimizing stimulatory effects * Ramp up and ramp down was over 10 s. (Ref. Loo CK et al., Br J Psychiatry 2012;200:52-9)

Treatment:

Device: transcranial direct current stimulation (tDCS)