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The Effect of Two Exercise Training Protocols on Physiological and Biochemical Parameters in Congestive Heart Failure

D

Dr. Robert Klempfner Heart Rehabilitation Institute

Status

Completed

Conditions

Heart Failure

Treatments

Other: Continues aerobic training
Other: Interval exercise training

Study type

Interventional

Funder types

Other

Identifiers

NCT02009475
LACT_HF_KIN

Details and patient eligibility

About

The aim of the present study is to evaluate differential lactate removal kinetics in heart failure patients that are trained according to 2 different exercise protocols:

(A) High intensity intervals training (HIT); (B) Continuous moderate aerobic training (MAT)

Full description

Introduction: Congestive heart failure (CHF) patients suffer from early fatigue and functional aerobic impairment. Their reduced cardiac output and O2 delivery to the peripheral muscles shifts those patients consistent anaerobic metabolism, thus, CHF patients rely on anaerobic metabolism even in everyday life activity. This metabolism leads to a shift of muscles fiber types from mainly slow twitch, oxidative type I fibers to fast twitch, glycolytic type IIb fibers. Monocarboxylate proteins MCT1 and MCT4 transport lactate crosses the membrane. MCT1 is responsible for the lactate uptake and MCT4 is responsible for efflux of excess lactate. Exercise training is known to improve the quality of life in CHF. We hypothesized that exercise training might change MCT1 and 4 expression and distribution. Accordingly, these changes may also affect lactate clearance during recovery, which may contribute to the beneficial effect of exercise training in CHF patients. Methods: New-York Heart association (NYHA) class II-III CHF patients will be assigned to the experiment. At baseline and upon training conclusion they will undergo the same tests battery. The test battery includes heart rate, blood pressure measurements, echocardiographic evaluation. All participants will fill out "Minnesota living with heart failure" questionnaire. Subsequently, after their basal blood lactate will be assessed they will undergo measurement which will be followed by lactate clearance-rate evaluation.

Randomly each patient will then be assigned to one of two experimental training groups: (A) High intensity intervals training (HIT); (B) Continuous moderate aerobic training (MAT). Each volunteer will be trained twice a week for 12 weeks, according to his/hers assigned training protocol and in accordance to exercise training guidelines.

Enrollment

29 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Stable heart failure patients referred to exercise training in a tertiary care cardiac rehabilitation institute
  • Age > 21

Exclusion criteria

  • Severe symptomatic heart failure
  • Severe orthopedic limitations
  • Unstable arrythmia
  • Cognitive decline or substance abuse
  • Unable to comply with exercise protocol
  • Significant pulmonary disease
  • NYHA 4 heart failure class

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

29 participants in 2 patient groups

Continues aerobic training
Active Comparator group
Description:
Treadmill or exercise bike training with target heart rate of 50-70% of the heart rate reserve (or 50-60% of the peak VO2 reserve). Overall 45 minutes of exercise (including the 5-10 minute warm-up period).
Treatment:
Other: Continues aerobic training
Interval Exercse Training
Experimental group
Description:
Bouts of high intensity interval treadmill or exercise bike training, comprising of 85-95% of the heart rate reserve (or 80-90% of the peak VO2 reserve), for the duration of 4 minutes, separated by periods of low intensity activity until the heart rate reaches 50% of the peak heart rate. This set will be repeated 3 times.
Treatment:
Other: Interval exercise training

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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