The Effect of Using Desensitizers Containing S-PRG In Treatment Of Dentin Hypersensitivity Over 6 Months: A Randomized Clinical Trial

Eman Omar Elfarouk

Status: Not yet enrolling

Conditions: Dentin Hypersensitivity

Treatments: Procedure: Tooth varnish (Clinpro white varnish 3M); Procedure: Tooth varnish (PRG Barrier Coat from Shofu)

Study type: Interventional

Funder types: Other

Identifiers

NCT06276777

SPRG Dentin Hypersensitivity

Details and patient eligibility

About

The goal of this clinical trial is to compare the effect of desensitizer containing S-PRG have similar effect as sodium fluoride with functionalized tri-calcium phosphate containing desensitizer in relieving dentinal hypersensitivity in adult patients for six months follow-up. patients will be asked to report pain degree on the visual analogue scale (VAS) along the follow up periods on both groups.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Good oral hygiene.
• Cooperative patients who show interest to participate in the study and welling to sign the informed consent.
• Healthy patients with no history of previous systematic diseases that can affect their oral health.
• Normal and healthy gingival tissue.
• Teeth that have no cavitation or restorations.
• Patients with at least 20 natural permanent teeth and at least two teeth with a VAS score from 4 to 10.
• Anterior teeth.

Exclusion criteria

• Allergic to the ingredients used in the study.
• Gastrointestinal disorders (They have repeated vomiting attacks).
• Medically compromised (They cannot tolerate the procedures).
• Taking desensitizing treatment in the last 6 months (It affects the outcome).
• Taking anti-inflammatory drugs (It affects the hypersensitivity perception).
• Pregnant females (They complain from nausea and repeated vomiting attacks)
• Smokers (Smoking will affect the oral hygiene and periodontal health).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 2 patient groups

Varnish contains S-PRG (PRG Barrier Coat from Shofu)

Experimental group

Description:

Treatment of dentin hypersensitivity by application of tooth varnish containing S-PRG.

Treatment:

Procedure: Tooth varnish (PRG Barrier Coat from Shofu)

Varnish contains sodium fluoride and functionalized tri-calcium phosphate(Clinpro white varnish 3M)

Active Comparator group

Description:

Treatment of dentin hypersensitivity by application of tooth varnish containing sodium fluoride with functionalized tri-calcium phosphate.

Treatment:

Procedure: Tooth varnish (Clinpro white varnish 3M)